A blood-based nutritional risk index explains cognitive enhancement and decline in the multidomain Alzheimer prevention trial.

Gene L Bowman,Hiroko H Dodge,Sophie Guyonnet,Nina Zhou, Juliana Donohue,Aline Bichsel,Jeroen Schmitt,Claudie Hooper,Tamas Bartfai,Sandrine Andrieu,Bruno Vellas

Alzheimer's & Dementia: Translational Research & Clinical Interventions（2019）

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摘要

•Multi-nutrient approaches may produce more robust effects through interactive properties•Nutritional risk index can objectively quantify nutrition-related cognitive changes•Optimum nutritional status associated with cognitive enhancement over 3-years•Suboptimum nutritional status associated with cognitive decline over 3-years•Optimizing this nutritional risk index may promote cognitive health in older adults

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关键词

Nutrient biomarkers,Metabolomics,Biomarkers of diet quality,Omega-3 fatty acids,DHA,EPA,Homocysteine,Vitamin D,Aging,Elderly,Cognitive decline

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