Inhibition of Fatty Acid Amide Hydrolase by Chlorpyrifos in Juvenile Rats Results in Altered Exploratory and Social Behavior as Adolescents.

Russell L Carr,Navatha Alugubelly, Kathryne de Leon,Louise Loyant,Afzaal N Mohammed, M Elizabeth Patterson,Matthew K Ross, Nicole E Rowbotham

NeuroToxicology（2020）

引用 24|浏览7

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摘要

•Chlorpyrifos (CPF) is an organophosphorus insecticide and suspected developmental neurotoxicant.•Repeated exposure of juvenile rats to CPF increased adolescent exploratory behavior and social play behaviors.•Repeated exposure of juvenile rats to a specific FAAH inhibitor also increased adolescent exploratory and social play behaviors.•Developmental brain FAAH inhibition is one mechanism responsible for the persistent effects of developmental CPF exposure.

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关键词

Chlorpyrifos,Developmental,Endocannabinoid,Fatty acid amide hydrolase,Social play

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