The colonic macrophage transcription factor RBP-J orchestrates intestinal immunity against bacterial pathogens.
JOURNAL OF EXPERIMENTAL MEDICINE(2020)
摘要
Macrophages play pleiotropic roles in maintaining the balance between immune tolerance and inflammatory responses in the gut. Here, we identified transcription factor RBP-J as a crucial regulator of colonic macrophage-mediated immune responses against the enteric pathogen Citrobacter rodentium. In the immune response phase, RBP-J promoted pathogen clearance by enhancing intestinal macrophage-elicited Th17 cell immune responses, which was achieved by maintenance of C/EBP beta-dependent IL-6 production by overcoming miRNA-17 similar to 92-mediated suppressive effects. RBP-J deficiency-associated phenotypes could be genetically corrected by further deleting miRNA-1792 in macrophages. In the late phase, noneradicated pathogens in RBP-J KO mice recruited abundant IL-1P-expressing CD64(+)Ly6C(+). colonic macrophages and thereby promoted persistence of ILC3-derived IL-22 to compensate for the impaired innate and adaptive immune responses, leading to ultimate clearance of pathogens. These results demonstrated that colonic macrophage-intrinsic RBP-J dynamically orchestrates intestinal immunity against pathogen infections by interfacing with key immune cells of T and innate lymphoid cell lineages.
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