Identification of the first cases of complete CD16A deficiency: association with persistent EBV infection.

A Pérez Portilla,M Moraru,Alfonso Blázquez Moreno,Philipp Kolb,María Bravo García-Morato,Thanmayi Ranganath,Gloria Esteso,Carla Gianelli,Rebeca Rodríguez-Pena,Roberto Lozano Rodríguez, Juan Manuel Torres-Canizales,Catherine A Blish,Mar Vales-Gomez,Hartmut Hengel,Carlos Vilches,Eduardo López Granados,Hugh T Reyburn

Journal of Allergy and Clinical Immunology（2020）

引用 11|浏览49

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摘要

This is the first description of CD16A-deficient humans. CD16A is essential for NK cell ADCC, but not natural cytotoxicity. Chronic EBV replication was a major clinical feature, suggesting that ADCC is important for immunity to EBV.

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关键词

Adaptive NK cells,CD16A,EBV,Immune deficiency

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