Aberrant mPFC GABAergic Synaptic Transmission and Fear Behavior in Neuroligin-2 R215H Knock-in Mice.

Jian Chen,Binbin Dong,Xiaoyi Feng,Dongyun Jiang,Gong Chen,Cheng Long,Li Yang

Brain Research（2020）

引用 15|浏览3

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摘要

•NL2 R215H KI results in reduction of GABAergic transmission and gamma oscillation.•KI mice show altered levels of GABAA γ2 subunit, vGAT, PV and thus E/I in the mPFC.•Aberrant E/I ratio may contribute to impairment of fear response in the KI mice.

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关键词

Neuroligin-2,mPFC,GABAergic transmission,E/I balance,Gamma oscillation,Schizophrenia,Transgenic mouse model

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