Bothrops moojeni venom and BmooLAAO-I downmodulate CXCL8/IL-8 and CCL2/MCP-1 production and oxidative burst response, and upregulate CD11b expression in human neutrophils

Luciana Simon Pereira-Crott,Tânia Mara Casare-Ogasawara,Luciana Ambrosio, Luiz Fernando Princi Chaim, Fabiana Rosseto de Morais,Adélia Cristina Oliveira Cintra,Nathália Cristina Canicoba,Luiz Fernando Fortunato Tucci,Maria Regina Torqueti,Suely Vilela Sampaio,Cleni Mara Marzocchi-Machado,Fabíola Attié de Castro

International Immunopharmacology（2020）

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摘要

•In neutrophils, BmV reduced IL-8 and MCP-1 production and BmooLAAO-I reduced only MCP-1 production.•The IL-8 and MCP-1 reduction was accompanied by CD11b upregulation and CD66b downregulation.•BmV and BmooLAAO-I suppressed the oxidative burst of neutrophils stimulated with PMA.•BmooLAAO-I suppressed the neutrophil response stimulated with opsonized zymosan.

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关键词

Human neutrophils,CXCL8/IL-8,CCL2/MCP-1,CD11b,Oxidative burst,Bothrops moojeni venom,L-amino acid oxidase,Immunomodulation,CD66b,Snake venoms,Snake toxins

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