Impact of RhoA overexpression on clinical outcomes in cervical squamous cell carcinoma treated with concurrent chemoradiotherapy.

Keiichi Tanaka,Yoshitaka Matsumoto,Hitoshi Ishikawa,Nobuyoshi Fukumitsu,Haruko Numajiri,Keiko Murofushi,Yoshiko Oshiro,Toshiyuki Okumura,Toyomi Satoh,Hideyuki Sakurai

Journal of Radiation Research（2020）

引用 11|浏览44

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摘要

The Rho-associated coiled-coil-containing protein kinase (ROCK) pathway is known to influence metastasis in several cancers; however, the impact of the pathway on clinical outcomes in patients undergoing radiotherapy remains unknown. In the present study, the expression of RhoA, RhoC, ROCK-1, ROCK-2 and p53 was immunohistochemically evaluated using biopsy specimens obtained from 49 patients with s...

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cervical cancer,prognosis,concurrent chemoradiotherapy,RhoA,cell adhesion

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