The impact of gender on diabetes-related lower extremity amputations: An Italian regional analysis on trends and predictors

•A significant reduction of LEAs was observed only for males. Clinicians should be aware that time trends did not showed an improvement for women.•Recording these disparities and identifying their predictable factors may help caregivers to provide higher standards of diabetes care.•Peripheral vascular disease was the leading predictor of major and minor amputations.Age over 85 and more than 3 comorbidities were parameters associated only with major amputations.•These findings may have important implications, in order to develop screening and prevention strategies targeted for women.