A synthetic transcription factor pair mimic for precise recruitment of an epigenetic modifier to the targeted DNA locus.

Zutao Yu,Mengting Ai,Soumen K Samanta,Fumitaka Hashiya,Junichi Taniguchi,Sefan Asamitsu,Shuji Ikeda,Kaori Hashiya,Toshikazu Bando,Ganesh N Pandian,Lyle Isaacs,Hiroshi Sugiyama

CHEMICAL COMMUNICATIONS（2020）

引用 10|浏览10

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摘要

We developed an epigenetically active, cooperative DNA binding transcription factor platform assisted by cucurbit[7]uril (CB7) host-guest modules. This new type of molecule termed ePIP-HoGu not only mimics the operation of transcription factors as a pair but also recruits the epigenetic modifier to a particular DNA locus.

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