Anti- and pro-oxidant effects of quercetin stabilized by microencapsulation on interstitial cells of Cajal, nitrergic neurons and M2-like macrophages in the jejunum of diabetic rats.

Flávia Cristina Vieira-Frez, Camila Caviquioli Sehaber-Sierakowski,Juliana Vanessa Colombo Martins Perles,Gleison Daion Piovezana Bossolani,Waldiceu Aparecido Verri, Rafael Campos do Nascimento, Flávia Alesandra Guarnier,Heloíza Paranzini Bordini, Fernanda Pachoal Blegniski,Heber Amilcar Martins,Sara Raquel Garcia de Souza,Fabiana Galvão da Motta Lima,Mariana Machado Lima,Bruna Thais Silva, Camila Cristina Iwanaga,Jacqueline Nelisis Zanoni

NeuroToxicology（2020）

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摘要

•The diabetes-induced oxidative stress affects interstitial cells of Cajal (ICC), nitrergic neurons and M2-like macrophages.•Quercetin-loaded microcapsules (100 mg kg−1) aggravated the diabetic condition with toxic activities to the healthy animals.•Quercetin-loaded microcapsules (10 mg kg−1) displayed desirable and protective effects on diabetic and healthy rats.

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关键词

Ano1,BSA,CAPES,CD206,D,DAPI,DQ10,DQ100,ECL,EDTA,GI,HRP,ICC,ICC-DMP,ICC-MY,IR,M1,M2,NANC,nNos,NO,NQ10,NQ100,ONOO−,PBS,QLM,RNS,ROS,RT,SDS,TX-100,ABAP,TRAP,TCA,DNPH2,4,RLU

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