Synthesis of New Cisplatin Derivatives from Bile Acids.

Barbara Seroka,Zenon Łotowski,Agnieszka Hryniewicka,Lucie Rárová,Rafal R Sicinski,Aneta M Tomkiel,Jacek W Morzycki

MOLECULES（2020）

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摘要

A series of bile acid derived 1,2- and 1,3-diamines as well as their platinum(II) complexes were designed and synthesized in hope to get a highly cytotoxic compound by the combination of two bioactive moieties. All complexes obtained were subjected to cytotoxicity assays in vitro and some hybrid molecules showed an expected activity.

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关键词

bile acids,lithocholic acid,deoxycholic acid,hyodeoxycholic acid,cholic acid,steroidal diamines,platinum(II) complexes

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