Methylation signatures in peripheral blood are associated with marked age acceleration and disease progression in patients with primary sclerosing cholangitis.

•A peripheral blood DNA methylation (DNAm) score identifies age acceleration in PSC patients vs. healthy controls.•PSC patients with high age acceleration had significantly more PSC-related events than those with low age acceleration.•These findings may enable stratification of at-risk PSC patients based on a DNAm score from peripheral blood.