Paternal Factors in Neurodevelopmental Toxicology: THC Exposure of Male Rats Causes Long-lasting Neurobehavioral Effects in Their Offspring.

•The offspring of THC-exposed male rats had significant locomotor hyperactivity during adolescence.•Paternal THC caused a greater drop-off in interest in the novel object during the second half of the test session.•Learning in the radial-arm maze was significantly delayed in the offspring of males exposed to THC.•This study shows that premating chronic paternal THC exposure causes long-lasting detrimental behavioral effects in their offspring.