Exploring predicted indirectly recognizable HLA epitopes (PIRCHE-II) in liver transplant recipients on calcineurin inhibitor-free maintenance immunosuppression. A retrospective single center study.

Magdalena Meszaros,Matthias Niemann,José Ursic Bedoya,Stéphanie Faure,Lucy Meunier,Benjamin Rivière, Valérie Costes-Martineau,Céline Thevenin,Georges-Philippe Pageaux

Transplant Immunology（2020）

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摘要

The PIRCHE (Predicted Indirectly ReCognizable HLA Epitopes) score is an HLA epitope matching algorithm. PIRCHE algorithm estimates the level of presence of T-cell epitopes in mismatched HLA. The PIRCHE-II numbers associate with de novo donor-specific antibody (dnDSA) formation following liver transplantation and kidney allograft survival following renal transplantation. The aim of our study was to assess the PIRCHE-II score in calcineurin inhibitor (CNI)-free maintenance immunosuppression recipients.

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关键词

HLA epitope mismatch,Immunosuppression minimization,Donor-specific alloantibodies

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