Acute kidney injury, fluid balance and risks of intraventricular hemorrhage in premature infants
JOURNAL OF PERINATOLOGY(2020)
摘要
Objective Evaluate association between fluid balance and intraventricular hemorrhage (IVH). Study design Retrospective review of infants <30 weeks gestation admitted to Kentucky Children’s Hospital Neonatal Intensive Care Unit. Results Infants with acute kidney injury (AKI) had a 2.4-fold increased risk of IVH (OR 2.38, 95% CI 1.46–3.87) and a 3.5-fold increased risk of severe IVH (OR 3.45, 95% CI 1.98–6.04). Infants above birthweight on day 4 had a 1.9-fold increased risk of IVH (OR 1.86, 95% CI 1.05–3.27) and a 2.0-fold increased risk of severe IVH (OR 1.96, 95% CI 1.03–3.74). When controlling for confounding factors, infants with AKI or above birthweight on day 4 had a 4.6-fold (aOR 4.60, 95% CI 1.80–11.78) and 3.0-fold (aOR 2.96, 95% CI 1.01–8.65) increased risk of severe IVH, respectively. Conclusion Infants with AKI during the first week of life had a higher association of severe IVH even after controlling for confounding factors.
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关键词
Acute kidney injury,Medical research,Medicine/Public Health,general,Pediatrics,Pediatric Surgery
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