Binding of metal ion induced tau oligomers to lipid surfaces is enhanced by GSK-3β mediated phosphorylation.

Georg S Nuebling,Eva Plesch,Viktoria C Ruf,Tobias Högen,Stefan Lorenzl,Frits Kamp,Armin Giese,Johannes Levin

ACS chemical neuroscience（2020）

引用 8|浏览12

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摘要

Our data imply a pathological gain of function of metal-ion induced oligomers of hyperphosphorylated tau, enabling membrane binding irrespective of surface charge even at nanomolar protein concentrations.

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关键词

Tau,oligomer,metal ion,lipid membrane,vesicle,scanning for intensely fluorescent targets

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