Full-length 5'RACE identifies all major HBV transcripts in HBV-infected hepatocytes and patient serum.

Bernd Stadelmayer,Audrey Diederichs,Fleur Chapus,Michel Rivoire,Gregory Neveu,Antoine Alam,Laurent Fraisse,Kara Carter,Barbara Testoni,Fabien Zoulim

Journal of Hepatology（2020）

引用 48|浏览19

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摘要

•HBV full-length 5'RACE discriminates all viral transcripts including HBx.•Viral particles contain pgRNA, pgRNA splice variants and different HBx RNAs.•HBx RNAs in viral particles are both capped and uncapped.•The composition of circulating viral RNA species can vary among patients.

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关键词

HBV transcripts,HBV viral particles,Serological HBV RNA,Hepatitis B,cccDNA

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