Altered anoctamin-1 and tyrosine phosphorylation in congenital ureteropelvic junction obstruction.

Manuela Hunziker,Anne-Marie O'Donnell, Jan Gosemann,Luis A Alvarez,Prem Puri

Journal of Pediatric Surgery（2020）

引用 4|浏览16

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摘要

We provide evidence, for the first time, of the presence of ANO1 expression in the human UPJ. We speculate that altered tyrosine phosphorylation, observed in UPJ obstruction, may lead to a failure of transmission of peristaltic waves in UPJ obstruction by inhibiting Ca-activated chloride channels in SMCs.

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关键词

Ureteropelvic junction,Kidney,Peristalsis,Anoctamin 1

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