Real-World Data and Physiologically-Based Mechanistic Models for Precision Medicine.
CLINICAL PHARMACOLOGY & THERAPEUTICS(2020)
摘要
The assessment of a therapeutic window for pharmaceutical compounds requires the integration of multidimensional data. In this perspective, we highlight how the increased volume of medical and healthcare data, and, in particular, real-world data (RWD), can be integrated within physiologically based modeling framework. We illustrate this perspective view with specific case studies related to pharmacokinetic and cardiac safety predictions.
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