Hesperetin-5,7,3'- O -Trimethylether Dually Inhibits Phosphodiesterase 3/4 and Methacholine-Induced Airway Hyperresponsiveness in Sensitized and Challenged Mice.

Chung-Hung Shih,Wen-Hung Wang,Chi-Ming Chen,Wun-Chang Ko

DRUG DESIGN DEVELOPMENT AND THERAPY（2020）

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摘要

HTME exerted anti-inflammatory and bronchodilator effects and may be useful in treating chronic obstructive pulmonary disease and allergic atypical asthma with no gastrointestinal side effects.

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关键词

allergic asthma,bronchoalveolar lavage fluid,chronic obstructive pulmonary disease,cytokines,inflammation,ovalbumin,therapeutic PDE4H/PDE4L ratio

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