Surface-PASylation of ferritin to form stealth nanovehicles enhances in vivo therapeutic performance of encapsulated ellipticine

Applied Materials Today（2020）

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摘要

•PEG/PAS-surface-coated ferritins with encapsulated ellipticine were constructed.•PAS-modifications markedly reduced uptake of ferritins in macrophages in vitro.•PAS-modifications inhibited formation of surface protein corona.•PAS-10 ferritins accumulated prefentially in breast tumor tissue.•PAS-10 ferritins exhibited exceptional biocompatiblity in vivo.

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关键词

Biocompatibility,Breast carcinoma,Cancer therapy,Ferritin,PASylation,PEGylation

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