Enhancement of antitumor effect of radiotherapy via combination with Au@SiO2 nanoparticles targeted to tumor-associated macrophages

Mi Sun Kim,Jae Sang Lee,Jung Eun Kim,Jae-Won Kim,Seoyeon Bok,Ki Chang Keum,Won-Gun Koh,Woong Sub Koom

Journal of Industrial and Engineering Chemistry（2020）

引用 8|浏览24

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摘要

•Au@SiO2 (GNPs) were conjugated with CD163 antibody to target M2 TAM (CD163-GNPs).•M2 TAM-targeting capacity of CD163-GNPs was demonstrated.•Radiotherapy combined with CD163-GNPs showed more effective tumor growth delay than radiation alone.•Combination radiotherapy decreased the number of M2 TAMs, increasing M1 TAMs.

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关键词

TAM,AuNP,RT,NP,PVP,TEOS,APTES,ANB-NOS,DI,PBS,BMDM,FBS,FACS,RT-qPCR,IL,LPS,IFN,MHC II,APC,CTCF,TGD,iNOS,TNFα,Arg1,TEM,FTIR,STAT,NFκB

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