Measure Twice: Promise of Liquid Biopsy in Pediatric High Grade Gliomas

Purpose: To review and critique the current state of liquid biopsy in pHGG. Materials and Methods: Published literature was reviewed for articles related to liquid biopsy in pediatric glioma and adult glioma with a focus on high-grade gliomas. Results: This review discusses the current state of liquid biomarkers of pHGG and their potential applications for liquid biopsy development. Conclusions: While nascent, the progress toward identifying circulating analytes of pHGG primes the field of neuro-oncoogy for liquid biopsy development. (C) 2020 The Author(s). Published by Elsevier Inc. on behalf of American Society for Radiation Oncology.