An integrated pathway based on in vitro data for the human hazard assessment of nanomaterials

Daina Romeo,Beatrice Salieri,Roland Hischier,Bernd Nowack,Peter Wick

Environment International（2020）

引用 48|浏览5

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摘要

•Reduction of in vivo data limits nanoparticles assessment by risk methodologies.•A combination of in vitro data and in silico models is proposed.•In silico models are evaluated for their implementability with available data.•Recommendations for the use of in vitro data in risk methodologies are provided.

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关键词

Risk assessment,Life cycle assessment,Effect factor,Quantitative in vitro in vivo extrapolation,In silico models,Nanoparticles toxicity

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