Imaging and histopathologic correlates of plasma cell-free DNA concentration and circulating tumor DNA in adult patients with newly diagnosed glioblastoma.

Seyed Ali Nabavizadeh,Jeffrey B Ware,Samantha Guiry,MacLean P Nasrallah, Jazmine J Mays,Jacob E Till,Jasmin Hussain,Aseel Abdalla,Stephanie S Yee,Zev A Binder,Donald M O'Rourke,Steven Brem,Arati S Desai,Ronald Wolf,Erica L Carpenter,Stephen J Bagley

Neuro-oncology advances（2020）

引用 14|浏览80

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摘要

Metrics of BBB disruption and quantity and distribution of tumor-associated macrophages are associated with plasma cfDNA concentration and ctDNA detection in GBM patients. These findings represent an important step in understanding the factors that determine plasma cfDNA concentration and ctDNA detection.

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关键词

MRI,cfDNA,ctDNA,glioblastoma,histology

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