RET isoform-specific interaction with scaffold protein Ezrin promotes cell migration and chemotaxis in lung adenocarcinoma.

•RET51 isoform interacts with scaffold protein Ezrin and Src in lung cancer cells.•RET-Src-Ezrin signaling mediates activation of RhoA and ROCK1/2.•Enhanced RET signaling promotes cytoskeletal reorganization for chemotaxis.•RET-Ezrin signaling drives lung cancer metastasis.•RET and Ezrin selective inhibitors present unique options for treating lung cancer.