Advanced quantitative proteomics to evaluate molecular effects of low-molecular-weight hyaluronic acid in human dermal fibroblasts.

Silvia Radrezza,Giovanna Baron,Sarath Babu Nukala, Gabriele Depta,Giancarlo Aldini,Marina Carini,Alfonsina D'Amato

Journal of Pharmaceutical and Biomedical Analysis（2020）

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摘要

•Low-molecular-weight hyaluronic acid influenced intra- and extra-cellular proteome.•Label free proteomics allowed a complete vision of molecular impact on fibroblast.•Safety and benefits for dermal use were confirmed.

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关键词

HA,LMW-HA,HMW-HA,nLC-HRMS

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