Exhausted phenotype of follicular CD8 T cells in CVID

Adam Klocperk,Susanne Unger,David Friedmann,Maximilian Seidl,Katharina Zoldan,Jens Pfeiffer,Oliver Hausmann,Vladimir Benes,Geoffroy Andrieux,Tobias Boettler,Anna Sediva,Bertram Bengsch,Klaus Warnatz

Journal of Allergy and Clinical Immunology（2020）

引用 14|浏览30

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摘要

Follicular CD8 T cells are expanded in germinal centers of CVID patients with lymphadenopathy, show increased proliferation, an exhaustion-associated phenotype and IL-10 production and may thus potentially contribute to germinal center dysregulation in some CVID patients.

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关键词

CD8 T cell,CVID,CXCR5,IL-10,exhaustion,follicular CD8 T cell,germinal center,immunodeficiency,lymph node

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