Absence Of Significant Association Betweenugt2b4genetic Variants And The Susceptibility To Anti-Tuberculosis Drug-Induced Liver Injury In A Western Chinese Population

What is known and objective Combination regimens of six-month duration may increase the incidence of anti-tuberculosis drug-induced liver injury (ATLI), which is clinically characterized by mild cholestasis and hepatocanalicular lesions.UGT2B4is a predominant UDP-glucuronosyltransferase enzyme in the human liver that plays an important role in the detoxification of bile acids, which yields water-soluble inactive compounds that can easily be excreted in the bile or urine. This study aimed to investigate the potential association betweenUGT2B4variants and the susceptibility to ATLI. Methods Genomic DNA was extracted from whole blood sample of each patient, and all SNPs were genotyped using an improved multiplex ligation detection reaction method. Clinical symptoms and laboratory results were recorded regularly. Five genetic variants atUGT2B4(rs1131878, rs1966151, rs28361541, rs4557343 and rs79407331) were identified in a prospective study of 118 ATLI cases and 628 non-ATLI controls. All participants were treated by first-line anti-TB drugs in Western China Hospital. The potential association between SNPs, ATLI risk and clinical phenotypes were determined based on the distribution of allelic frequencies and different genetic models. Results and discussion Statistical comparisons of cases and controls after correction for multiple testing did not yield any significant association between genetic variants atUGT2B4and risk of ATLI via the analyses of single locus and subgroup differences. What is new and conclusion This is the first study aimed to investigate the association ofUGT2B4polymorphisms with ATLI risk. Our results revealed thatUGT2B4genetic variants are unlikely to confer susceptibility to ATLI in the Western Chinese Han population.