Back Cover: Theranostic Layer-by-Layer Nanoparticles for Simultaneous Tumor Detection and Gene Silencing (Angew. Chem. Int. Ed. 7/2020)

Layer-by-layer nanoparticles functionalized with protease-responsive peptide biomarkers and loaded with siRNA mediate noninvasive urinary-based diagnostics in mouse models of three different cancers with simultaneous gene silencing in flank and metastatic mouse models of ovarian cancer. This work provides a modular nanotheranostic platform to both perturb and characterize tumors, allowing for simultaneous treatment and monitoring of disease, as reported by P. T. Hammond et al. in their Research Article on page 2776.