A step towards personalizing next line therapy for resected pancreatic and related cancer patients: A single institution's experience

Cinthya Y. Lowder,Teena Dhir,Austin B. Goetz,Henry L. Thomsett,Joseph Bender,Talar Tatarian,Subha Madhavan,Emanuel F. Petricoin rd,Edik Blais,Harish Lavu,Jordan M. Winter,James Posey,Jonathan R. Brody,Michael J. Pishvaian,Charles J. Yeo

Surgical Oncology（2020）

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摘要

•How precision medicine can be used in PDA.•Highlighting the use of NGS and protein expression in PDA tumor samples.•NGS uncovered actionable alterations in 48% of resected PDAs (48%).•NGS can be used to guide therapy options in the future.•High levels of TS, ERCC1, and PD-1 proteins were associated with decreased in RFS.

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