Synthesis, Characterization, DNA Interaction and Docking Studies of Novel Schiff Base Ligand Derived from 2,6-Diaminopyridine and Its Complexes

In this study [1-(4-{[(3-hydroxynaphthalen-2-yl)methylidene]amino}phenyl)ethan-1- one (B1 ligand) were synthesized from the reaction of 2-hydroxy-1-naphthaldehyde with 4-amino-acetophenone. Following that 1-(N-{4-[(1)-1-({6-[(Z)-[1-(4-{[(3- hydroxynaphthalen-2-yl) methylidene]amino}phenyl)ethylidene]amino]pyridin–2- yl}imino)ethyl]phenyl}carboximidoyl)naphthalen-2-ol (L1 ligand) were synthesized from the reaction of 2,6-diamino pyridine with B1 ligand. Using this Schiff base ligand Cu(II), Fe(II) and Pd(II) complexes were prepared. The structure of the ligand and its complexes were determined by 1H NMR, FTIR, UV–Vis, elemental analysis, thermal analyses and magnetic susceptibility spectral data. Further, DNA binding properties of the ligand and its metal complexes were investigated and docking studies were carried out. As a result ligands and copper complex showed DNA binding activity and an increase with H2O2. According to these results it can be suggested that these compounds are very suitable drug candidates.