Copy Number Assessment in the Genomic Analysis of CNS Neoplasia: An Evidence-Based Review from the Cancer Genomics Consortium (CGC) Working Group on Primary CNS Tumors

•Overview of the assessment of genomic findings in the diagnostic workup of CNS neoplasia.•Technical and organizational approaches to genomic assessment of copy number aberrations.•A comprehensive yet concise review of the most important genomic findings in select CNS tumors.•Annotations regarding diagnostic relevance as established by the WHO and other organizations.•Multiple illustrations to demonstrate techniques in the genomic assessment of CNS neoplasia.