Nrf2 in early vascular ageing: Calcification, senescence and therapy

•Nrf2 termed as the master regulator of antioxidant responses.•Oxidative stress is recognized as a trigger of cellular senescence.•Nrf2 may be beneficial against senescence, calcification and early vascular ageing.•Natural and synthetic Nrf2 agonists have been introduced in different phases of clinical trials.