Synthesis of magnetite loaded fluorescence micelles of triblock copolymer

Magnetic micelles with fluorescence dyes were fabricated by self-assembly of triblock copolymer followed by in situ templated coprecipitation method. Nile red was encapsulated into the polystyrene core of the triblock copolymer confirmed by fluorescence measurement. The magnetic nanoparticles are selectively chemisorbed on the poly(acrylic acid) (PAA) shell of polymeric micelles due to ionic interaction between PAA and Fe ions. The negatively charged PAA also a platform to bind positively charged drug molecules. The hydrophilic poly(ethylene glycol) (PEG) corona stabilizes the micelles composites. The multifunctional polymeric micelles were well characterized by using different tools and techniques: dynamic light scattering, transmission electron microscope, UV–visible spectrophotometer, fluorescence spectroscope, and magnetometer.