Erg6 affects membrane composition and virulence of the human fungal pathogen Cryptococcus neoformans.

Fabiana Freire M Oliveira,Hugo Costa Paes, Luísa Defranco F Peconick,Fernanda L Fonseca,Clara Luna Freitas Marina,Anamélia Lorenzetti Bocca,Mauricio Homem-de-Mello,Márcio Lourenço Rodrigues,Patrícia Albuquerque,André Moraes Nicola,J Andrew Alspaugh,Maria Sueli S Felipe,Larissa Fernandes

Fungal Genetics and Biology（2020）

引用 20|浏览9

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摘要

•Erg6 is required for Cryptococcus neoformans high temperature growth.•ERG6 deletion impairs susceptibility to stress and antifungal agents.•Sterol membrane composition affects virulence of human fungal pathogen.

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关键词

Sterol C-24 methyltransferase,Ergosterol,Virulence,Membrane sterol composition

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