DNA-nanorobot-guided thrombin-inducing tumor infarction: raising new potential clinical concerns.

•DNA NanorobotTh-ITI is an emerging powerful therapeutic modality for solid cancer.•DNA NanorobotTh-ITI specifically induces tumor infarction and massive necrosis.•DNA NanorobotTh-ITI is comparable with other effective anticancer modalities but with less toxicity.•DNA NanorobotTh-ITI is being transitioned from the preclinical setting to clinical translation.•New potential clinical concerns of DNA NanorobotTh-ITI are being raised.•Further studies are required for addressing these new potential concerns.