Triketone-terpene meroterpenoids from the leaves of Rhodomyrtus tomentosa

Eight new meroterpenoids (1-8) featuring beta-triketone-conjugated terpenoids, rtomentones A-H, were isolated from the leaves of Rhodomyrtus tomentosa. Structures of the isolates were unambiguously established by a combination of NMR and ECD spectroscopy and X-ray diffraction analysis. Rtomentone C (3) was the first example of aromadendrane-based meroterpenoid containing an oxa-spiro [5.6] ring. Rtomentone D (4) was obtained as a racemic mixture confirmed by chiral HPLC analysis. The cytotoxicity against MDA-MB-231, A549, and DLD-1 cells of all isolates was evaluated.