Copper signalling: causes and consequences
Cell Communication and Signaling(2018)
摘要
Copper-containing enzymes perform fundamental functions by activating dioxygen (O 2 ) and therefore allowing chemical energy-transfer for aerobic metabolism. The copper-dependence of O 2 transport, metabolism and production of signalling molecules are supported by molecular systems that regulate and preserve tightly-bound static and weakly-bound dynamic cellular copper pools. Disruption of the reducing intracellular environment, characterized by glutathione shortage and ambient Cu(II) abundance drives oxidative stress and interferes with the bidirectional, copper-dependent communication between neurons and astrocytes, eventually leading to various brain disease forms. A deeper understanding of of the regulatory effects of copper on neuro-glia coupling via polyamine metabolism may reveal novel copper signalling functions and new directions for therapeutic intervention in brain disorders associated with aberrant copper metabolism.
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关键词
Redox disproportionation and speciation of copper,Dynamic copper pool,Copper-rich aggregates,GSH/GSSG ratio,Copper chelate therapy,Neuro-glia coupling
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