Genotoxic and cytotoxic properties of two medical plants (Teucrium arduini L.and Teucrium flavum L.) in relation to their polyphenolic contents

Darko Grujičić,Aleksandra Marković,Jovana Tubić Vukajlović,Milan Stanković,Marina Radović Jakovljević,Andrija Ćirić,Katarina Djordjević,Nevena Planojević,Milena Milutinović,Olivera Milošević-Djordjević

Mutation Research/Genetic Toxicology and Environmental Mutagenesis（2020）

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摘要

•T. arduini and T. flavum extracts were investigated for genotoxicity and cytotoxicity.•Both extracts induced micronuclei and DNA damage in cultured human lymphocytes.•Both extracts were evaluated for cytotoxicity in MRC-5 and MDA-MB-231 cells.•Cytotoxicity was observed with both extracts in MRC-5 cells only.

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3,5-DHBA,3-HBA,AlCl3,ANOVA,BN,CBMN,CACO-2,C32,COR-L32,DMEM,DMSO,DNA,EDTA,FBS,GAE,GDI,HCT-116,HeLa,HPLC,K562,KCL,LMPA,MMC,MN,MTT,MRC-5,MDA-MB-231,NaCl,NaOH,NDI,RUE,SD,Tris–HCl

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