Dissecting the differential structural and dynamics features of CCL2 chemokine orthologs

Nidhi Joshi
Nidhi Joshi
Nupur Nagar
Nupur Nagar
Khushboo Gulati
Khushboo Gulati
Krishnakant Gangele
Krishnakant Gangele

International journal of biological macromolecules, pp. 239-251, 2020.

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Keywords:
ChemokinesG-protein coupled receptor (GPCR)Glycosaminoglycans (GAGs)Molecular evolutionNuclear magnetic resonance (NMR)

Abstract:

Chemokines are a sub-group of cytokines that regulate the leukocyte migration. Monocyte chemoattractant protein-1 (MCP/CCL2) is one of the essential CC chemokine that regulates the migration of monocytes into inflamed tissues. It has been observed that the primary sequences of CCL2 orthologs among rodents and primates vary significantly a...More

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