Increased angiotensin II from adipose tissue modulates myocardial collagen I and III in obese rats.

Danielle Cristina Tomaz da Silva-Bertani,Danielle Fernandes Vileigas,Gustavo Augusto Ferreira Mota,Sérgio Luiz Borges de Souza,Paula Grippa Sant'Ana,Paula Paccielli Freire,Loreta Casquel de Tomasi,Camila Renata Correa,Carlos Roberto Padovani,Tiago Fernandes,Edilamar Menezes de Oliveira,Antonio Carlos Cicogna

Life Sciences（2020）

引用 6|浏览40

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摘要

It has been described that the cardiac dysfunction in the obesity model is because of collagen imbalance and that angiotensin II (Ang II) contributes to myocardial fibrosis. However, it remains undefined if changes in collagen I and III metabolism in obesity is due to the renin-angiotensin system (RAS) dysregulation from myocardium or excessive adipose tissue.

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关键词

High-fat diet,Obesity,Heart,Renin-angiotensin system,Losartan,Collagen

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