PREPARATION OF ORAL CURCUMIN DELIVERY FROM 3D-NANO-CELLULOSE NETWORKS MATERIAL PRODUCED BY ACETOBACTER XYLINUM USING OPTIMIZATION TECHNIQUE

Objective: To prepare oral curcumin delivery and optimize curcumin loading of 3D-nano-cellulose networks material (3DCM) by looking into the impact of process variables on the response utilizing response surface methodology (RSM) and Box-Behnken design. Methods: Optimization of curcumin loading of 3DCM was conducted using RSM and Box-Behnken model. Impact of four independent variables, including, the concentration of curcumin (X1), temperature (X2), shaking speed (X3), and time of loading (X4), was studied on one dependent response, that is, an amount of loaded curcumin (Y). Characterization of optimized 3DCM including curcumin was examined by Scanning Electron Microscopy (SEM) and Fourier Transform Infrared (FTIR) analysis . Results: R2 value for Y was approximately 0.94. X1 possessed the biggest positive impact compared to X2, X3 and X4. Optimized conditions for curcumin loading of 3DCM were X1 at 3 mg/ml, X2 at 40 °C, X3 at 120 rpm and X4 at 120 min. SEM photograph of 3DCM surfaces were found including fibers creating a 3D network structure. FTIR spectra studies depicted that there was no interaction between curcumin and 3DCM. Conclusion: The data obtained in this study thus suggest that curcumin loaded 3DCM was successfully fabricated to give a potential oral delivery system of curcumin.