P70 Effects of Different Vitamin D Status on Mechanical, Pharmacological and Histological Characteristics of Coronary Arterioles in Male Rat Model

The cardiovascular/CV risk is higher in males. To know better these increased risks, our aim was to investigate the effects of different vitamin D/VD status on mechanical, pharmacological and histological characteristics of coronary arterioles in male rat model. In male Wistar-rats we induced different VD status: “Group C” got 1000 IU VD containing rat chow and VD-supplementation, “Group D-” got less, than 5 IU VD containing rat chow to model the VD deficient/VDD status. At the end of the experiment we prepared intramural, small coronary arteriole segments from the LAD. With microangiometer, we measured the inner and outer diameters, TXA2-vasoconstriction, adenosine-vasorelaxation, and the passive diameter. Histopathological examinations were taken. Inner and outer radius were significantly decreased, wall thickness and wall-thickness/lumen diameter ratio were significantly increased in group D-, while the wall-cross-sectional area and the intima-media area