Contribution of Oxyanion Stabilization to Kemp Eliminase Efficiency

Hajo Kries,Joël S. Bloch,H. Adrian Bunzel,Daniel M. Pinkas,Donald Hilvert

ACS Catalysis（2020）

引用 13|浏览8

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摘要

Important reactions in biology and biocatalysis involve proton abstraction from carbon. When the resulting anionic charge is delocalized from carbon to an oxygen atom, these deprotonations can be c...

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关键词

oxyanion hole,enzyme design,Kemp elimination,active site mutagenesis,kinetic isotope effect

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