The 2-/16α-Hydroxylated Estrogen Ratio-Breast Cancer Risk Hypothesis: Insufficient Evidence for its Support: Running title: 2-/16α-Hydroxyestrone-Breast Cancer Risk Hypothesis.
The Journal of Steroid Biochemistry and Molecular Biology（2020）
摘要
•Many studies have tested the 2-/16-hydroxyestrogen ratio-breast cancer risk theory.•There are deficiencies in assay specificity and/or accuracy in those studies.•Use of the 2-/16-hydroxylated estrogen pathway ratio as a biomarker is questionable.•Assays for unconjugated 2-OH-E1 and E2, and 16α-hydroxy-E1 in serum are needed.•Serum/urine assays for intact conjugated forms of relevant estrogens are also needed.
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关键词
Breast cancer,Estrogens,2-hydroxyestrone,16α-hydroxyestrone,Estrogen metabolism,Mass spectrometry
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