Diabetes mellitus exacerbates citrin deficiency via glucose toxicity.

Yoriko Watanabe,Chikahiko Numakura,Toshiyuki Tahara,Kaori Fukui,Takuji Torimura,Yuji Hiromatsu,Ken Tomotsune,Mitsunori Yamakawa,Kiyoshi Hayasaka

Diabetes Research and Clinical Practice（2020）

引用 4|浏览30

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摘要

Glucose is not toxic for citrin deficiency in normoglycemia because glucose uptake and metabolism by hepatocytes are limited in normoglycemia. However, glucose becomes toxic during persistent hyperglycemia and antidiabetic therapy is indispensable for CTLN2 patients with DM.

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关键词

Citrin deficiency,Adult-onset type II citrullinemia (CTLN2),Glucose toxicity,Diabetes mellitus

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