Anidulafungin and Micafungin concentrations in Cerebrospinal Fluid and in Cerebral Cortex.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY(2020)
摘要
Anidulafungin and micafungin were quantified in cerebrospinal fluid (CSF) of critically ill adults and in cerebral cortex of deceased patients. In CSF, anidulafungin levels (<0.01 to 0.66 mu g/ml) and micafungin levels (<0.01 to 0.16 mu g/ml) were lower than those in plasma concentrations (0.77 to 5.07 and 1.21 to 8.70 mu g/ml, respectively) drawn simultaneously. In cerebral cortex, anidulafungin and micafungin levels were 0.21 to 2.34 and 0.18 to 2.88 mu g/g, respectively. Thus, MIC values of several pathogenic Candida strains exceed concentrations in CSF and in brain.
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关键词
echinocandins,antifungal target-site pharmacokinetics,CNS penetration,fungal meningoencephalitis,CNS candidiasis,critically ill
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