TAOK1 positively regulates TLR4-induced inflammatory responses by promoting ERK1/2 activation in macrophages.

Lingxi Zhu,Qingzhuo Yu,Peng Gao,Qianru Liu,Xiaogang Luo,Guixian Jiang,Ruihua Ji,Rui Yang,Xianwei Ma,Jing Xu,Hongbin Yuan,Jun Zhou,Huazhang An

Molecular Immunology（2020）

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摘要

•TAOK1increases TLR4-induced cytokine production in macrophages;•Decreased systemic inflammatory responses in TAOK1 deficient mice;•TAOK1 interacts with TRAF6 and TPL2 and then promotes TLR4-triggered ERK1/2 activation.

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关键词

TAOK1,TLRs,LPS,TRAF6,IL-6

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