Proteomic analysis involved with synaptic plasticity improvement by GABAA receptor blockade in hippocampus of a mouse model of Alzheimer’s disease

Keiichi Kadoyama,Kenji Matsuura,Masaoki Takano,Mieko Otani,Takami Tomiyama,Hiroshi Mori,Shogo Matsuyama

Neuroscience Research（2021）

引用 7|浏览9

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摘要

•Bicuculline improves impaired synaptic plasticity in the dentate gyrus of AD mice.•The expression of 11 proteins is changed for recovering process in the hippocampus.•These proteins play important roles in recovery from impaired synaptic plasticity.•GABAA receptor blockade might contribute to AD cure.

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关键词

Bicuculline,Alzheimer’s disease,Hippocampus,Synaptic plasticity,Proteome

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